소개글
[화장품화학] Ceramide에 대한 자료입니다.
목차
1 .Study of Safety of Pseudo-ceramide
2. Study of Clinical Efficacy of a Multi-Lamellar Emulsion containing Pseudo-ceramide
- on Atopic Dermatitis
- in childhood Atopic Dermatitis
본문내용
1. On the effects of topical synthetic pseudoceramides : Comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 & Bio391, and natural ceramides.Result
Cell growth ◦ Cell toxicity
Discussion
PC-104, BIO319 have fewer adverse effects on cell growth and toxicity than nature-identical Cer in intact CHK.
Two pseudo-Cer have no evidence of toxicity, skin sensitization, mutagenicity and neither skin nor eye irritation.
MLE (Multi-Lamellar Emulsion)
지방산, 콜레스테롤과 함께 유사세라마이드를 포함하는 지질혼합물
피부 각질층 성분과 유사
대부분 oil-in-water emulsion
AD (Atopic Dermatitis)
Ceramide 부족이 원인
Objective
An Open clinical crossover evaluation was conducted to investigate the effects in Atopic Dermatitis(AD) of a multi-lamellar emulsion(MLE) that contained pseudoceramide(PS-9S). - Control group : CMC (Commercial moisturizing cream : 5% urea)
참고문헌
Yoshikazu Uchida 외 2명(2008). On the effects of topical synthetic pseudoceramides: Comparison of possible keratinocyte toxicities provoked by the sweudoceramides, PC104 and BIO391, and natural ceramides. Journal of Dermatological Science. Vol.51, 37-43.
김진국 외 5. 신규 유사세라마이드의 합성과 그 특성. J. Soc. Cosmet. Scientists Korea. Vol. 34, No. 1, March 2008, 43-50
박원석 외 5명. Improvement of skin barrier function using lipid mixture. J. Soc. Cosmet. Scientists Korea. Vol. 27, No.1, March 2001, 53-72
Eun ju Lee 외 6명(2003). The clinical Efficacy of a Multi-Lamellar Emulsion Containing Pseudoceramide in Childhood Atopic Dermatitis : An Open Crossover Study. Annals of Dermatology. Vol. 15,No.4
박병덕 외 1. Atopic Dermatitis and Ceramides. The Journal of Skin Barrier Research. Vol2. No.2.September 2000,27-35.
Jae Sung Hwang 외 7명. Improved skin hydration and SCORAD index with unique lipid mixture carrier(DermaON) for atopic dermatitis. 학술대회. Vol. 2008 .No.1 2008
Sang-Hyun Cho. Clinical efficacy of pseudoceramide-containing multi-lamellar emulsion(MLE)on skin barrier function and its application as vehicle for topical drugs including steroid. 초록집.Vol.47.No.20.2009
Byeong Deong Park 외 2명(2001). The Clinical Efficacy of Multi-Lamellar Emulsion Contained Pseudoceramid(PC-9S) on Atopic Dermatitis. The JSBR. Vol.3.No.1. 81-87