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[유전공학] 다발성 내분비 종양증 Multiple Endocrine Neoplasia(type 1&2)(영문)에 대한 자료입니다.
목차
MEN
MEN – autosomal dominant disease
MEN1- Definition & History
MEN1- Gene & Protien
MEN1 – Gene structure
MEN1- Gene & Protien
MEN1 – Protein location and function
MEN1 – Animal Model & Therapy
MEN2 – definition
MEN2 – disease
RET gene
RET germline mutations – MEN phenotype
Animal model - Drosophila
Receptor Tyrosine Kinase (RTK)
Animal model - Drosophila
본문내용
MEN2A & FMTC(familial MTC) : 95%
MEN2B : 5%
Same genetic mutation
Different clinical manifestations
MTC(Medullary Thyroid Cancer)
Excessive production of calcitonin
Diarrhea, flushing
Pheochromocytoma
Excessive catecholamines
Headache, sweating, heart rate
Parathyroid adenoma
Hyperparathyroidism
Neurinoma = Schwannoma
Nerve tumor composed of Schwann cells
Journal - A Drosophila Model of Multiple Endocrine Neoplasia Type 2 by the Genetics Society of America 171: 1057–1081 (November 2005)
Drosophila retina
: a model for RTK(Receptor Tyrosine Kinase) signal
transduction
: Ret gene encodes for RTK