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분야
pptx2.Oncogenes, Tumor suppressors,
and the Warburg effect
3. Oncogenic activation of HIF
and the Aerobic glycolysis
4. PDK1 and Aerobic glycolysis
5. Tumorigenesis and the Aerobic glycolysis
HIF-1은 산소에 민감한 HIF-1α subunit과 HIF-1β subunit이heterodimer를 형성하여 DNA 에 결합
HIF-1의 안정화는 angiogenesis를 유발
산소가 풍부한 상황에서 HIF-1α는 PDH(prolyl hydroxylases)에 의해TCA cycle에서 나온 a-ketoglutarate를 사용하여 hydroxylated
Tumor suppressor 단백질
hydroxylated HIF-1α 는 VHL에 의해 인식 proteasome에서 분해
HIF-1α는 저산소환경이 아닌 상 황에서는 계속 합성되고 분해됨
