[반응공학] Nano diagnosis technology(영문)에 대한 자료입니다.
1. Definition of nanotechnology
2. History of nanotechnology
3. Application of nanotechnology
3. 1 Medicine
3. 2 Energy
3. 3 Information technology
3. 4 Consumer goods
4. 1 Nanotechnology-based biochips and microarrays
4. 2 Protein Microarrays/Chips
4. 3 Nanobiosensors
4. 4 Nanobarcodes
5. Contacting patterns
5. 1 Biochip
5. 2 Drug delivery system
5. 3 Mechanisms of drug deliver
5. 4 Multifunctional nanoparticles for diagnostics and drug delivery
5. 5 Biosensors
6. General theory kinetics
6. 1 Burk-phase transport
6. 2 Surface-phase kinetics
6. 3 Theory of hybridization kinetics for well-spaced probes
6. 4 thermodynamic stability of hybridization and dissociation kinetics
6. 5 Nonspecific adsorption kinetics
7. Economic impacts
7. 1 Medical impact
7. 2 Food safety
7. 3 Other applications
8. Socio-cultural impact
8. 1 Aging society
8. 2 Early checkup
8. 3 U-health
5.2 Drug Delivery System
5.2.1 Advantage of Nano-drug delivery system
By diagnosis, and for treatment, we need enhanced drug delivery system. Drug delivery system of these days is just eat and let it flow through the body. It is not good at efficiency. Because the digestive system sometimes digest and remove the drug before it reaches to the target.
For enhancing the efficiency of drug delivery system, we can use nanotechnology, especially nanoparticles that can carry the drug molecules to the target safely.
5.2.2 Nanocarriers - Nanoparticles
Before starting with the functionalization of nanoparticles, it is important to keep in mind a range of useful properties we wish to have in any drug delivery across the BBB(Blood brain barrier). In this context, owing to their small size, customizable surface, improved solubility, targeted drug delivery and multifunctionality, nanoparticles have emerged as potential drug delivery carriers to tissues throughout the body. Yet passing the BBB is particularly difficult. The proper design of such engineered ‘nanocarriers’ becomes very important in transversing the impermeable membranes to facilitate drug delivery. At the same time, it is also required to retain the drug stability and ensure that early degradation of drugs from the nanocarriers does not take place.
Therefore, for drugs to be successfully delivered to their target, many factors such as its size, biocompatibility, target specific affinity, avoidance of reticuloendothelial systems, stability in blood, or ability to facilitate controlled drug release need to be considered during manufacture of the nanoparticles. Ideal conditions, or wish-list, of any drug are difficult to meet simultaneously. As for nanocarriers to serve as good candidates for drug delivery across the BBB can be summarized as follows.
- particle diameter less than 100 nanometers;
- non-toxic, biodegradable and biocompatible;
11. Nanotechnology and Its Applications in Medical Diagnosis, K. Rajasundari and K. Ilamurugu Department of Agricultural Microbiology, Tamil Nadu Agricultural University, Coimbatore 641003, India.