[생물정보] 렙틴(leptin)

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 19  [생물정보] 렙틴(leptin)-19
 20  [생물정보] 렙틴(leptin)-20
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[생물정보] 렙틴(leptin)에 대한 자료입니다.
목차
1.Adipose tissue
2. What is Leptin ?
3.Role of Leptin
4.Similar structure
5.Protein BLAST
6.BLAST vs PSI-BLAST
7.Natural variation region
8.Leptin Motif
9.Jailview
10.LOGO
11.Phylogeny Tree DND File
본문내용
Leptin is a hormone that is involved in the long term regulation of body weight. The word comes from the Greek word “leptos”, meaning thin. It is produced primarily by fat cells, but cells in the gut and placenta also make leptin. It circulates in the blood and acts on different tissue including the hypothalamus, skeletal muscle, and liver. Leptin is a protein that consists of 167 amino acids and has a molecular weight of about 16 kD or 16,000 g/mol. The DNA sequence for the protein was determined by Friedman in 1994 and was found on the obese (ob) gene [4]. The leptin receptor, the molecular structure on the cell surface that binds with leptin, is encoded by the diabetes (db) gene.

Leptin is a 16-kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. Leptin acts through the leptin receptor (LEPR; 601007), a single-transmembrane-domain receptor of the cytokine receptor family, which is found in many tissues in several alternatively spliced forms. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.

명칭
Leptin
구성
16kDa Protein
분비 장소
Adipose Tissue(지방세포)
유전 정보 위치
사람 : 7번 염색체, 쥐 : 6번 염색체
역할
호르몬으로써 시상하부로 가서 여러 가지 기작을 조절.