[발생공학] 배아 줄기 세포 연구(영문)
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[발생공학] 배아 줄기 세포 연구(영문)에 대한 자료입니다.
목차
What are embryonic & adult stem cells?

What are the advantages of adult stem cells, compared to embryonic stem cells?

Where are they and how are they isolated?

What can we do with the stem cells?
본문내용
Stem cell calssification
1. Based upon location

Embryonic stem cells

Somatic/ adult stem cells


2. Based upon function

Totipotent

Pluripotent

Multipotent

Unipotent


Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-repressents
& high tolerance

3 Co-stimulatory Drugs
참고문헌
What are embryonic & adult stem cells?
Thomson et. al; Itskovitz-Eldor, J; Shapiro, SS; Waknitz, MA; Swiergiel, JJ; Marshall, VS; Jones, JM (November 1998). "Blastocysts Embryonic Stem Cell Lines Derived from Human". Science 282 (5391): 1145–1147. doi:10.1126/science.282.5391.1145. PMID 9804556.
Thomson, James A.; Zwaka (10). "Homologous recombination in human embryonic stem cells". nature biotechnology 21 (3): 319–321. doi:10.1038/nbt788. http://www.nature.com/nbt/journal/v21/n3/full/nbt788.html. Retrieved 19 August 2011.
Andrews P, Matin M, Bahrami A, Damjanov I, Gokhale P, Draper J (2005). "Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin". Biochem Soc Trans 33 (Pt 6): 1526–30. doi:10.1042/BST20051526. PMID 16246161.


Martin GR (1980). "Teratocarcinomas and mammalian embryogenesis". Science 209 (4458): 768–76. doi:10.1126/science.6250214. PMID 6250214.
Evans M, Kaufman M (1981). "Establishment in culture of pluripotent cells from mouse embryos". Nature 292 (5819): 154–6. doi:10.1038/292154a0. PMID 7242681.
Martin G (1981). "Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells". Proc Natl Acad Sci USA 78 (12): 7634–8. doi:10.1073/pnas.78.12.7634. PMC 349323. PMID 6950406.www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=349323.
Thomson J, Itskovitz-Eldor J, Shapiro S, Waknitz M, Swiergiel J, Marshall V, Jones J (1998). "Embryonic stem cell lines derived from human blastocysts". Science 282 (5391): 1145–7. doi:10.1126/science.282.5391.1145. PMID 9804556.



What are the advantages of adult stem cells, compared to embryonic stem cells?
Hwang YS 외 5명, Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11, Proc Natl Acad Sci USA, 2009
Yang F 외 7명, Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D, Biomacromolecules, 2010
Mitra Lavasani 외 10명, Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model, Nature communications, 2012
Kitai Kim,1,2,4 Paul Lerou,1,4,5 Akiko Yabuuchi,1,2,4 Claudia Lengerke,1,2,4 Kitwa Ng,1,2,4 Jason West,1,2,4 Andrew Kirby,6 Mark J. Daly,6 George Q. Daley1,2,3,4*, Histocompatible Embryonic

November 2007: Human induced pluripotent stem cells: Two similar papers released by their respective journals prior to formal publication: in Cell by Kazutosi Takahashi and Shinya Yamanaka, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors“, and in Science by Junying Yu, et al., from the research group of James Thomson, "Induced pluripotent stem cell lines derived from human somatic cells“: pluripotent stem cells generated from mature human fibroblasts.

Where are they and how are they isolated?
http://www.sumanasinc.com/webcontent/animations/content/stemcells_scnt.html The New England Journal of Medicine.Volume 349:570-582, August 7, 2003,Number 6
http://www.ldysinger.com/ThM_599d_Beg/06_Stem-Cell/04_NEJM_adut-stem1.htm
Adult Cells, Reprogrammed To Embryonic Stem Cell Like State, Treat Sickle-Cell Anemia In Mice
ScienceDaily (Dec. 6, 2007)
PNAS April 29, 2008 vol. 105 no. 17 6332-6337 http://www.pnas.org/content/78/12/7634.short

November 2007: Human induced pluripotent stem cells: Two similar papers released by their respective journals prior to formal publication: in Cell by Kazutosi Takahashi and Shinya Yamanaka, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors“, and in Science by Junying Yu, et al., from the research group of James Thomson, "Induced pluripotent stem cell lines derived from human somatic cells“: pluripotent stem cells generated from mature human fibroblasts.

What can we do with the stem cells?
K. J. Godfrey 외 5명, Review Article Stem cell-based treatments for Type 1 diabetes mellitus:
bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells, DIABETICMedicine, 2011
Jong-Hoon Kim 외 10명, Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease, Nature, 2002
www.bcellbio.co.kr
www.bestcell.co.kr
http://www.yonhapnews.co.kr/society/2012/01/12/0706000000AKR20120112068500009.HTML
http://www.hankyung.com/news/app/newsview.php?aid=2010101831951


http://www.edaily.co.kr/news/NewsRead.edy?newsid=02315686599528920&SCD=DH34&DCD=A00710
http://www.cnn.com/2008/HEALTH/12/22/stem.cell.drug.tests/index.html
BYUNG-SOON PARK, MD, PHD,_y KYOUNG AE JANG, MD,y JONG-HYUK SUNG, PHD, et al. Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging. American Society for Dermatologic Surgery. 2008;34:1323–1326.
Kotaro Yoshimura Æ Katsujiro Sato Æ Noriyuki Aoi, et al. Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation : Supportive Use
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