분야
pptxIntroduction
Tumor?
Delivery method
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Nanoparticle for cancer therapeutics
Multistage nanoparticle delivery
How to cause the size change?
Structure of QDGelNPs
Result using QDGelNPs
References
Introduction
Nowadays, the method of chemotherapy + radiation is widely used because it is more effective for cancer cells than normal cells.
However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects.
So finding less toxic agents and choosing a precise delivery system is a task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
[2] Mark E. D., et al. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nature Review Drug Discovery
7, 771-782 (2008)
[3] Stephane M., et al. Magnetic nanoparticle design for medical diagnosis and therapy. J. Mater. Chem. 14, 2161-2175 (2004)
[4] Gao X., Cui Y., et al. In vivo cancer targeting and imaging with Semiconductor quantum dots. Nature Biotechnology 22, 969-976 (2004)
[5] Fabienne D., et al. Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation. Journal of Controlled Release 133, 11–17 (2009)
