Glimepirde(Amaryl) 레포트

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Glimepirde(Amaryl) 레포트에 대한 자료입니다.
목차
History of sulfonyurea
Mechanism of drug action
SAR study
Synthesis of Glimepiride
Clinical Trials
Glimepiride & Marketing
Reference
본문내용
History of sulfonylurea

IPTP for typhoid fever(장티푸스) in early 1940s
Many patients died. – acute & prolonged hypoglycemia
Carbutamide
effective oral hypoglycemic
Firtst sulfonyluea hypoglycemic

참고문헌
http://www.drugs.com/pro/amaryl.html
http://dric.sookmyung.ac.kr/NEWS/sep97/newdrug.htm
사노피 공식 배포자료
임상시험의 통계학적 방법 대한간질학회지 2006;10(2):71-77 명성민·김신영
Overview of Current Therapeutic Options in Type 2 Diabetes John B. Buse, MD, PHD
http://www.doctorsnews.co.kr/news/articleView.html?idxno=82623
Medical chemistry. New Age international publishers. Ashutosh Kar
2011 의약품산업 분석보고서. KHIDI 한국보건산업진흥원
The Molecular Mechanism of the Insulin-mimetic/sensitizing Activity of the AntidiabeticSulfonylurea Drug Amaryl.Günter Müller.Aventis Pharma Germany, Frankfurt, Germany. Accepted August 8, 2000.
Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels. Wanda H. Vila-Carriles*, Guiling Zhao† and Joseph Bryan†
A Transmembrane Domain of the Sulfonylurea Receptor Mediates Activation of ATP-Sensitive K+ Channels by K+Channel Openers . Nathalie D’hahan, Hélène Jacquet, Christophe Moreau, Patrice Catty and Michel Vivaudou