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분야
pptMATERIALS AND METHODS
Result
Discussion
HELICOBACTER PYLORI -> chronic inflammatory, intestinal metaplasia, dysplasia, and finally adenocarcinoma
cag pathogenicity, which encodes a type IV secretion system (T4SS)
-> more severe inflammation, gastric cancer
proinflammatory + mitogenic stimuli -> COX-2 -> 위 상피세포 -> PGE2 -> 암
PGE2 -> tumor growth, angiogenesis, inhibiting apoptosis, inducing invasion, and suppressing immune activation
H pilory 감염 (Cag T4SS, H. pylori soluble factor) -> EGFR 활성 -> COX-2 증가
Direct interaction between H. pylori and gastric epithelial cells -> full induction of COX-2 expression
A functional cag T4SS is required for this process
COX-2 : 아라키돈산 -> 프로스타 글란딘 (EP receptors)
PGE2 결합 EP1~EP4
