single-nucleotide polymorphisms (SNPs), including 6 SNPs within exons and 18 SNPs within the putative 5‘ regulatory region of the porcine LEPR gene. Among them, one SNP (-790C/G) was significantly associated with backfat thickness and lean meat pe
Single Nucleotide Polymorphism (SNP)
DNA sequence variation occurring when a single nucleotide –A, T, C, G- in the genome (or other shared sequence) differs between members of a biological species or paired chromosomes in an individual.
Variations in the DNA sequences of humans can affect how humans develop diseases and respond to drugs, pathogens, vaccines, chemicals, and other agents.
Abstract—We designed high-throughput microchip which detects single nucleotide polymorphisms (SNPs). The chip consisted of DNA extraction part and SNP detection part. DNA was extracted by lysis buffer, and then amplified by polymerase chain reaction (PCR). In SNP detection part, CEL I endonuclease selectively cleaved mismatched dsDNA, so wild type DNA was distinguished from mutant type. Sig