1. Introduction
1.1 광역학 반응
Photodynamic reaction(PDT)는 빛, 광민감제, 산소 이 세 가지 요소를 포함한다. 먼저 광민감제 또는 그것의 대사적 전구체를 환자들에게 투여한다. 특정 파장의 빛을 조사하면 광민감제는 낮은 에너지 상태인 ground state에서 높은 에너지 상태인 excited singlet state로 전환된다. 그 다
In this preliminary study, the variability of COX-2 overexpression in cervical premalignant lesions was assessed.
NSAIDs and COX-2 inhibitors show anti-cancer activities in many cancer cells.
Aspirin showed strongest inhibitory effects on viability and survival of YD-8 cells.
Aspirin treatment resulted in severe cell shrinkage and nuclear DNA fragmentation in YD-8 cells.
active targeting. Most of cancer cell have these receptor. Selection of molecules which target this receptor should be made.
For our strategy to use double targeting, we use special peptide pHLIP(pH Low Insertion Peptide). Cancer cells accumulate pyruvate due to insufficient O2 and consequent decrease of oxidative phosphorylation. So H+ pumps transport protons to extracellular fluid to maint
.
Ex. 니트로겐 머스타드계: 니트로겐 머스타드, 클로람부실, 멜팔란, 사이클로포스파마이드
클로람부실(Chlorambucil) :orally-active antineoplastic aromatic nitrogen mustard,
chlorambucil은 세포 주기의 모든 기간동안 DNA를 알킬화 하고, 교차 결합시켜 DNA의 기능을 붕괴시키고 Cell cycle arrest와 apoptosis가 일어나게 한다.
anticancer properties of cruciferous vegetables, most active isothiocyanate is sulfor-aphane.
Dosage: 500 to 2000mgs daily in divided oral dose.
Sprouts contain 20 to 50 times more sulforaphane in much greater quantity than mature broccoli.
Boiling reduce the levels of anti-cancer compounds in broccoli
Safety - No toxic data available, generally considered safe for appications and as veget