(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
Peptide 결합의 특성
- 단백질에서 아미노산은 한 아미노산의 알파-카르복실기와 다른 아미노산의 알파-아미노기의 아미드 결합인 펩타이드 결합으로 공유결합 되어 있다. 예를 들면 발린과 알라닌은 펩타이드 결합을 통해 dipeptide인 바닐릴알라닌을 형성할 수 있다.
- 펩타이드 결합은 열이나 고농도
Mid-1800s - Beginning research of Embryo
1908 – ‘Stem Cell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stem cell
1981 - Embryonic stem cell
1998 - Human's embryonic stem cell
2001 – First human embryo cloning
(중략)
2.1 Adult Stem Cell - How?From Bone Marrow
HSCs and MSCs are rich in b
Introduction
Nowadays, the method of chemotherapy + radiation is widely used because it is more effective for cancer cells than normal cells.
However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects.
So finding less toxic agents and choosing a precise delivery system is a task currently important.
Regulation of nan
▦ Physiologic Action of Gut Hormones
Criteria
① Peptide must be related into blood during time that a biologic response in a target organ is being stimulated or inhibited
② IV infusion of pure natural peptide must reproduce the effect on target organ
③ Synthetic peptide should reproduce the effect found with natural peptide
④ Circulating concentration of peptide that cause stimulat