Box1. 혈중 종양세포의 정량
혈중 종양세포(circulating tumorcells, CTCs)의 개수는 종양 전이의 민감한 생체지표이다. 따라서 CTC 정량은 암을 진단하고 단계를 판별('staging')하는데 그리고 잔존질환이 있는지를 조사하는데에 유용한 방법으로 떠오르고 있다. 이러한 임상적 중요성 때문에, 이 떠오르는 기술은
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
▦ Physiologic Action of Gut Hormones
Criteria
① Peptide must be related into blood during time that a biologic response in a target organ is being stimulated or inhibited
② IV infusion of pure natural peptide must reproduce the effect on target organ
③ Synthetic peptide should reproduce the effect found with natural peptide
④ Circulating concentration of peptide that cause stimulat
Introduction
Nowadays, the method of chemotherapy + radiation is widely used because it is more effective for cancer cells than normal cells.
However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects.
So finding less toxic agents and choosing a precise delivery system is a task currently important.
Regulation of nan
cells especially.
First of all, we can raise a question on its efficacy. To make this new concept of curing cancer to be
widely available, a high NSC/tumorcell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express an enzyme, then
implanted the transduced NSCs along with a rat glioma cell line