History of sulfonylurea
IPTP for typhoid fever(장티푸스) in early 1940s
Many patients died. – acute & prolonged hypoglycemia
Carbutamide
effective oral hypoglycemic
Firtst sulfonyluea hypoglycemic
1. Graves’ disease
-antithyroid drug: PTU, carbimazole, methimazole
-radioiodine: 131I
2. Acute Gastro-Enteritis
-GFS f/u
Thyrotoxicosis is defined as the state of thyroid hormone excess and is not synonymous with hyperthyroidism
But, the major etiologies of thyrotoxicosis are hyperthyroidism caused by Grave’s disease, toxic MNG, and toxic adenomas
2. Pathogenesis (cont.)
A clinical syndrome characterized by discomfort in the chest, jaw, shoulder, back, or arm
Typically aggravated by exertion or emotional stress and relieved by nitroglycerin
(ACC/AHA 2002 guideline)
병명이 아니고 흉통을 특징으로 하는 임상증상, 가역적 (cf. MI)
선진국의 주요한 사망원인 중 하나
임상증상이 매우 다양한 양상을 보임
허혈성
Clinical Causes of Edema
- Obstruction of Venous (and Lymphatic)Drainage of a Limb
정수압이 막힌부분으로 증가가 되면서 fluid의 비정상적인양이 혈관계로부터 간질공간으로 전달되게 된다. 다른 루트가 막히게 되면서, Limb에서 간질액의 증가가 일어나, fluid가 말단에 트래핑된다. 따라서 국소적 부종이 나타나게 된다.