COMT Inhibitors
▶ 크롬친화성 세포종 환자에 투여시 고혈압 위기의 위험을 증가
▶ Non-selective MAO inhibitors (phenelzine, tranylcipromine)및
Selective MAO-A,B inhibitors 와는 병용투여 금지.
▶ Cathechol기를 포함한 약물의 대사를 간섭하여 그 작용을 증강시킬 수 있다.
Amantadine
▶ 알려진 연장된 QT간격(Bazett Q
depends largely on endogenous factors, such as the individual's innate immunologic and nonimmunologic defenses and level of function of cell-mediated immunity (CMI).
The most potent risk factor for tuberculosis among infected individuals is clearly HIV co-infection, which suppresses cellular immunity. The risk that latent M. tuberculosis infection will proceed to active disease is directly rel
disease와 연관된 ganglioside GM2는 특히 뇌의 신경조직에서 일반적으로 발생한다.
5. 원인
1)Hexosaminidase A의 불충분한 활성으로 인해 지질이 뇌에 축적되어 질병 야기시킴.
(Hexosaminidase A: 리소좀에서 발견되는 지질을 분해하는 중요한 가수분해 효소임)
2)Hexosaminidase A의 subunit 2가지 단백질, GM2 activator prote
activator protein releases the newly formed GM3 ganglioside
"Another devastating genetic disease of children, called Tay-Sachs, has largely been eradicated through carrier screening. We want to follow that model," said Craig Benson. "There are hundreds of these conditions that, individually, are very rare. However, when taken as a group they are much more commonplace. It is the Foundation's
Many CNS diseases were thought to result from imbalances of neurotransmitters. Different neurotransmitters were known to activate different receptors just as different keys might open up different doorways.
Various classes of neurotransmitters, such as dopamine, norepinephrine, and serotonin, were associated with differing diseases. For example, Serotonin was associated with a variety of condit