MAPK에 대한 초기 연구는 동물세포가 growth factor를 인식하여 signal을 세포 안으로 전달하여 mitogen을 activation 시키는 mechanism을 밝히는 과정에서 시작되었다.
세포막 안으로 Growth facrot의 signal이 전달되면, Grb2가 Sos에 bindin화고, 이는 Ras-GDP를 Ras-GTP로 바꿔준다. 이는 Raf라는 MAPKKK(MAP kinanse kinase kinase)를 phosph
코카인
코카인의 효과는 암페타민과 비슷하지만 좀 더 짧다. 코카인이 코로 흡입된(snorted) 후 쾌감과 행복감을 느끼고 5분 후 freeze라고 불리는 무감각 상태(numbing sensation)가 된다. 암페타민과 마찬가지로 기운이 넘치고 정신이 뚜렷해 지는 것을 느끼는데, 20-30분 간 지속되며 그 후에 comedown 또는 letdown
tolerate her moods.
You call that moods. I call it rudeness.
But Marcel tolerates her...
Daddy is admirable, and tolerance is a rare virtue.
Very true. And hes always in a good mood.
Even now business is not going so well. -Oh, really?
You know more about his worries than me.
I stay out of it, and I like to keep it that way.
I have my problems and he has his.
A while ago I asked some advice about
freezing cold!.
Close the window. Hai! (yes).
Chiyo, Chiyo, come quickly.
Hatsumomo is at the bath-house
-Here tidy up.
-But she told me to stay ... !
Hatsumomo does not run this okea.
Look whos in my room...
Did you touch this?
I can just hear the General now why
Hatsumomo, you used to smell of jasmine,
What this new perfume? Blowfish?
I told you to never to touch my
things. Can you understand w
freezing winter morning. The boys
are being awakened by a monk, loudly ringing a bell.
Candles are lit.
Napoleon, age 9, sun-tanned, leaps out of bed, rubbing his
arms and shivering. He tries to pour a pitcher of water,
discovering that it has frozen solid.
NAPOLEON
Who has been putting glass in my
pitcher? Look here, someone has
filled my pitcher with glass!
DUFOUR
Oh, my goodness! Someone has f