Autoimmune hepatitis
Autoimmune hepatitis (AIH) is a disorder of unknown cause characterized by unresolving inflammation of the liver and by the presence of interface hepatitis on histologic examination (Fig. 1-1), hypergammaglobulinemia, and autoantibodies. Diagnosis requires the exclusion of other chronic liver diseases that have similar features, including Wilson disease, chronic viral hep
Abstract
Abacavir (ABC) is a nucleoside analog reverse trascriptase inhibitor (NRTI) used to treat HIV and AIDS. The pharmacogenetics of abacavir are relate to the human leukocyte antigen B (HLA-B) gene and its variant allele *57:01. This particular allele has been strongly associated with abacavir hypersensitivity. Limited research has been conducted in this area, though some potential exists
의 유전적 결핍은 매우 드묾지만, Coding , promoter region에 allergic variants가 있는 경우가 있다
이런 유전자들의 전사는 cytokines, transforming growth factor β, leptin, endothelin, vitamin D3, endotoxin, corticosteroids에 의해 조절된다
위에 대한 한 예로, LTC4 synthase 발현은 interleukin-4 이 up-regulate하고 endotoxin이 down-regulate 한다
variant of CYP1B1와 백인들의 유방암 위험성간의 관련성이 조사됨
그러나 폐암의 위험도와 이 polymorphism간에는 전혀 관련성이 없다고 주장되어 옴
estradiol 의 4-hydroxylation
-> carcinogenic estradiol-3,4-semiquinones과 quinone 형성
여성에서 estrogen -> CYP1B1 의 노출촉진
흡연 -> CYP1B1효소의 발현 촉진
활발한 tobacco