Mechanism
Figure shows the mechanism for GM2 ganglioside degradation by beta-hexosaminidase A.
The GM2 activator protein binds to GM2 ganglioside which is attached to the lysosome's membrane phospholipids.
It then forms a complex with beta-hexosaminidase A by binding to the alpha-subunit.
Once this complex is formed, it can hydrolyze the beta-1,4-linked N-acetylhexosamine residue trans
Country level managers reported directly to regional directors where as competitors as Holderbank had an extra layer of area managers between regional and country managers
-> Direct communication
Vice presidents of 7-9 departments of a plant report (standardized format) every month to the country president and the regional manager
-> Quicker communication thanks to standardized reports
sequence of events,
you’ll probably suer a fatal setback. The odds are not with you: As new research by Harvard
Business School’s Shikhar Ghosh shows, 75% of all start-ups fail.
But recently an important countervailing force has emerged, one that can make the process of
starting a company less risky. It’s a methodology called the “lean start-up,” and it favors
experimentation over elabo
sequence of events, you’ll probably suffer
more
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a fatal setback. The odds are not with you: As new research by
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