Stemcell calssification
1. Based upon location
Embryonic stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
1908 - The term "stemcell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stemcells.
1998 - James Thomson and coworkers derive the first human embryonic stemcell line at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
Endothelial Cell Coculture Within Tissue-Engineered
Cardiomyocyte Sheets Enhances Neovascularization
and Improves Cardiac Function of Ischemic Hearts
Department of Cardiovascular MedicineInstitute of Health BiosciencesThe University of Tokushima Graduate School
Limitation
Lack of organ donors
Complications associated with immune
suppressive treatments
hematopoietic stemcells)
(1) 특징
조혈간 세포의 특징은 자가복제, 증식(proliferation)과 분화(differentiation)를 한다.
(2) 분류
1) Pluripotent stemcells
주요 골수계세포인 적혁구계, 과립구, 단구계 및 거핵세포계 세포뿐만 아니라 림프구계 세포도 분화가 가능한 모세포가 존재하는것으로 알려져 있다. 이들 모
cell . 모든 종류의 세포로 분화될 능력을 가진 세포 . ex) 수정란
- Pluripotent cell
. 몸을 구성하는 세포를 만드는 능력을 가진 세포
. ex) ICM, 배아줄기세포
- Multipotent cell
. 특정 계통으로만 분화가능한 세포
. ex) Hematopoietic stemcell
Specialized cell
. 분화가 완료되어 특정 기능을 하는 세포
. ex