cellular constituent.
Vascular structures, nerves, skin ppendages.
Hypodermis (fatty layer)
Adipose tissue plus connective tissue.
Anchors skin to underlying tissues.
Shook absorber and insulator.
Advantages
- Made in large quantities and frozen for storage and shipping
- Artificial skin does not contain immunogenic cells such as
dendritic cells and capillary endothelial cells,
it
1.1.2. Cyclooxygenase-prostanoid cascade
Figure 1.1. Metabolism of arachidonic acid
Despite the diverse chemical structure of aspirin-like drugs, the antinociceptive effect of NSAIDs is mainly due totheir common property of inhibiting cyclooxygenases involved in the formation of prostanoids. Prostanoids areformed by most cells and act as autocrine and paracrine lipid mediators. They are n
1908 - The term "stem cell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stem cells.
1998 - James Thomson and coworkers derive the first human embryonic stem cell line at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
일어나며. 이러한 세포의 작용을 조절하는 호르몬은 epidermal growth factor (EGF)에 의해 일어난다. 한편 macrophage에 분비되는 interleukin-l (T-cell maturation)을 분비한다.
* EGF: mouse의 submaxillary gland에서 처음으로 분리된 6kDa의 polypeptide로 사람에서는 소변에서 분리한 EGF를 베타-urogastron으로 불려지기도 하였다.
Stem cell calssification
1. Based upon location
Embryonic stem cells
Somatic/ adult stem cells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re