depends largely on endogenous factors, such as the individual's innate immunologic and nonimmunologic defenses and level of function of cell-mediated immunity (CMI).
The most potent risk factor for tuberculosis among infected individuals is clearly HIV co-infection, which suppresses cellular immunity. The risk that latent M. tuberculosis infection will proceed to active disease is directly rel
Ⅰ. 개요
우리나라의 결핵유병률은 지난 약 40년간의 강력한 국가결핵관리사업으로 5.1%에서 1.03%로 매년 감소하고는 있으나 인구 10만 명당 결핵환자수가 429명, 전염성환자 수는 9만1천명이나 되고, 후천성면역결핍증환자도 매년 증가하고 있어 국가결핵관리사업의 중요성이 증가하고 있는 실정이다(
Socioeconomic Factors
No significant differences were found between cases and controls on most of the variables.
employment groups (p = 0.029)
meat consumption (p = 0.012)
chicken consumption (p = 0.034)
Malnutrition
세포매개면역을 저하시킨다.
higher point prevalence of infection in undernourished patients or community dwellers
worse and more frequent complications of infect
80% of all new cases of tuberculosis were limited to the lungs
Symptoms and signs:
Nonspecific and insidious,
consisting mainly of fever and night sweats, weight loss, anorexia, general malaise, and weakness
Cough: nonproductive ->purulent sputum, blood streaking
Hemoptysis
Pleuritic chest pain
Dyspnea
Rales in the involved areas du
6-10mm주사. 48-72시간 후 induration의 직경을 측정한다. Delayed type hypersensitivity. 10mm이상이면 양성이다.
위양성 : BCG접종, NTM, 치유된 결핵
2) IGRA : IFN-gamma release assay
결핵 특이항원에 대해 IFN-gamma분비를 보는 검사. TST보다 특이도가 높다(위양성이 적다) 요즘 대부분 쓰는 검사. 특히 Latent TB검사시 이용