Under the Hyperleptinemia condition
PPARα is increased during the rapid loss of fat
An Experiment of PPARα+/+ and PPARα-/- mice
→ Food intake and weight are reduced in both mice
but fat is reduced only in PPARα+/+
Under the Hyperleptinemia condition fat disappears in 7 days without any relation which is about quantity of free FA or ketone
→ Thus WAT is transformed to Fat b
콜린성 수용체 등에 길항
Pharmacokinetics (ADME)
Absorption
Almost complete
경구투여 시 first-pass effect로 생체이용률 60-70%
Distribution
95%는 혈장단백질 결합
반감기 : 약 12시간
Metabolism
Cytochrome P450에 의해 대사
Norclozapine : pharmacologically active
CYP1A2 inducer : smoking
CYP1A2 inhibitor : theophylline, ciprofloxacin, fluvoxamine
Genetic, i.e. heritable (even if there are no other cases in family).
2. It is primary myopathy (as defined by clinical, histologic, and EMG criteria).
3. No histologic abnormalities other than degeneration and regeneration of muscle fibers + reaction to those changes (infiltration by fat and connective tissue); no abnormal storage of metabolic products.
4. All symptoms are effects
서론
MHC?
- 모든 척추동물의 면역계와 자가면역에서 large gene family에 의해 암호화되는 세포표면분자
- 크게 ClassⅠ과 ClassⅡ 두 종류로 나뉨 ClassⅠ과 ClassⅡ 사이에 존재하는 Gene family를 ClassⅢ라 부름
MHC 작용 메커니즘
단백질 조각(항원)을 그 세포의 표면에 제시
위에 있는 T-cell이나 NK cell등