To make breakthrough progress in the molecular understanding of transcription and its regulation
disturbances in transcriptional regulation contribute cancer, inflammation, heart disease and metabolic diseases.
Essential to be able to direct this development to form only the wanted type of cells
Gene targeting in ES cell
1. ES cell culture
2. Construction of targeting vector
3. ES
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp
1. Introduction
1.1 광역학 반응
Photodynamic reaction(PDT)는 빛, 광민감제, 산소 이 세 가지 요소를 포함한다. 먼저 광민감제 또는 그것의 대사적 전구체를 환자들에게 투여한다. 특정 파장의 빛을 조사하면 광민감제는 낮은 에너지 상태인 ground state에서 높은 에너지 상태인 excited singlet state로 전환된다. 그 다
Liposomes
Liposomes are artificially prepared vesicles made of lipid bilayer.
Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases.
Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules.
Nano-particle drug carriers
Nano-particles are colloidal particles that range in size from 10 to 1000 nm i