Introduction
‘건강한 신체에 건강한 마음이 깃든다’
신체적 활동과 인지 기능과의 연관성
Hillman의 연구(2007)
Ahlskog의 메타분석연구(2011)
Parkinson’s Disease의 인지기능 손상
전 발달단계에 걸쳐 이러한 연관성이 존재
Basal Ganglia
Striatum (input)
Globus pallidus (output)
Direct Route
Striatum
→ Internal G
Development background
2. History of development
1960s
Discovery of colony-stimulating factors (CSF)
1980s
GM-CSF, M-CSF, G-CSF and multi-CSF
The human G-CSF was cloned
Usage for the treatment at first
1990s
first approval of Filgrastim by the US Food and Drug Administration
Launched Lenograstim
2000s
Launched PEG-filgrastim
Mechanism
낮은 pH 에 영향을 받지 않음
독소가 위 내 환경에 저항 할 수 있어, 소장(장내)에 독소가 작용하게 한다.
-toxin 은 proteolytic enzyme에 감수성이 있어 장관 내에서 proteolysis 기능 저지
trypsin, pepsin 치료에 감수성이 높다
실험동물에서, trypsin 이 toxin을 파괴하는
Neural circuitry
a.stress
The CRH (Corticotropin-releasing hormone) neurons of the Hypothalamus are controlled by two structures: the amygdale and hippocampus. The amygdale has significant role for fear responses. Sensory information enters the basolateral amygdale, where it is processed and relayed to neurons in the central nucleus. When the central nucleus of the amygdale becomes active,
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp