depressed patients have supported a popular hypothesis for depression involving decrements in neurotrophic factors – neurodevelopmentally expressed growth factors that also regulate plasticity within adult brain. From a serial of depression patients’ decreased volume of hippocampus and other prefrontal region was observed. This supports popular hypothesis including decrease of neurotrophi
3) 우울한 기분 depressed mood
불쾌한 기분 중에서 슬픔 sadness을 느끼는 기분을 말한다. 우울장애는 우울한 기분이 심하고 오래 지속된 병적인 상태를 말한다. 이때 환자는 대개 우울한 기분 뿐 아니라 죄책감, 자존심의 손상, 식욕 저하 등이 동반된다. 우울증 환자들은 자신의 우울한 기분을 직접 표현하
Mood is affected by the release of monoamine neurotransmitters including serotonin and norepinephrine.
Lack of neurotransmission at central serotonergic or noradrenergic synapses causes depression.
CRF and depression
Hyperactive HPA axis enhances CRF transmission in the hypothalamus.
Increased arousal, decreased appetite, decreased sexual behavior, and increased heart rate and blood pre