cell have these receptor. Selection of molecules which target this receptor should be made.
For our strategy to use double targeting, we use special peptide pHLIP(pH Low Insertion Peptide). Cancer cells accumulate pyruvate due to insufficient O2 and consequent decrease of oxidative phosphorylation. So H+ pumps transport protons to extracellular fluid to maintain normal cytoplasmic pH.
Th
cells are activated by mechanical trauma, cytokines and growth factors, etc. Conversionof arachidonic acid to prostanoid endproducts is carried out by cyclooxygenases (COX), also known as prostaglandin H synthase (PGHS), at two different sites on the enzyme.
Arachidonic acid is initially cyclized and oxidized to the endoperoxide PGG2 at the cyclooxygenase site of the COX and the product then re
2007년 논문에 의하면, 포유류의 UCP는 총 5종류(UCP1, UCP2, UCP3, UCP4, UCP5)가 있다. 이 중에서 생리적 기능에 대해 비교적 논란의 여지가 없는 것은 UCP1이고, UCP2와 UCP3는 생리적 기능이 계속해서 밝혀지고 있는 중이며, 나머지 UCP는 생리적 기능이 하나도 밝혀지지 않은 상태이다. 그래서 이 자료에선 UCP4, UCP5
Uncoupling (measured as thermogenesis) is only observed when the cells are adequately stimulated, for example, by
norepinephrine
Inhibitors – purine nucleotide
Activators – Free fatty acids
Heat production
Changes in Membrane potential – especially
proton motive force ↓
Fatty acid anion transport
activators, inhibitors
cell. These sources work respectively or simultaneously according to the driving condition to increase efficiency. Hybrid cars run on battery power at low speeds and switch to traditional internal-combustion at higher speeds. Since the capability of a secondary battery is not enough to replace the existing engine, it still needs to have both battery-powered motor and engine to generate enough pow