Histologically, the islets consist of three major and at least two minor cell types.
Beta cells, which synthesize and secrete insulin, make up about 60% of a typical islet.
Alpha cells are the source of glucagon, 30% of islet tissue.
Delta cell, which are less abundant, produce somatostatin.
F cells, which secrete pancreatic polypeptide.
Fifth cell type that secretes ghrelin.
Fifty cell typ
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
1.개요
유태인(Ashkenazi)에게 주로 발생하는 유전성 대사질환으로, 지질의 축적으로 인해 중추신경계의 점진적인 파괴를 유발하는 지질침착질환(Lysosomal storage disorder)이다. 1981년 영국의 안과의사 Warren Tay에 의해 처음 소개되었고, 몇 년 후 미국의 신경과 의사 Bernard Sachs에 의해 Tay-Sachs disease라 명명되
domains that most favor the deployment of
an arsenal of metaphors to persuade people. Research has suggested that three out
of four headlines or taglines in print ads use figurative words (Leigh 1994 ), a trend
that has increased over the past decades (Burgers et al. 2015; Proctor et al. 2005).
Likewise, advertisers frequently use metaphors to enhance consumers’ understanding
of the main ideas
Immunoglobulin E
in health and disease
Basic characteristics of IgE
IgE is the antibody isotype that contains the ε heavy chain and it is a monomer with five domains in the immunoglobulin structure
in plasma
- concentration of less than 1 μg/mL
in serum
- a half-life of about 2 days
Basic characteristics of IgE
IgE binds to its receptor FcεR,
High-affinity receptors (FcεRI)
-wide var