Ⅰ. 개요
만약 혈액보다 낮은 삼투압의 식염수에 혈액을 넣으면 혈구 속에 수분이 빨려 들어가 부풀어 마침내는 파괴된다. 이것을 용혈이라고 한다. 또 반대로 혈액보다 높은 삼투압의 식염수 안에서는 혈구 속의 수분이 밖으로 나와 혈구는 오그라들고 만다. 그리고 혈액과 같은 삼투압의 식염수를
건강한 성인 120명을 대상으로 30명씩 A, B, C, D 4그룹으로 나누어 각 그룹별로, A: Aspirin, Clopidogrel, B: Aspirin, Clopidogrel, Cilostazol, C: Aspirin, Clopidogrel, sarpogrelate, D:aspirin, sarpogrelate 의 약제를 일정한 시각에 복용하고 복용전과 plateletaggregation정도를 light transmittance aggregometry를 사용해 ADP 자극을 하여 비교한다.
platelet activation, potential resistance to thrombolysis
2) → conformational change in the glycoprotein ⅡbⅢa receptor.
→high affirnity for the sequence arginine-glycine-aspartic acid on the fibrinogen gamma chain
→ platelet cross-linking and aggregation
B. coagulation cascade is activated(← damaged endothelium에서 tissue factor
collagen fibrils
Granulation
Dense population of blood vessels,macrophages, and fibroblasts embedded within a loose provisional matrix of fibronectin, hyaluronic acid, and collagen
Be present in open wounds
Beefy-red appearance
Rich bed of new capillary networks that form by endothelial cell division and migration
VEGF be secreted by Platelet, activated macrophage, and fibroblast
Platelet, activated macrophage, and fibroblast
Epithelialization
Epidermal cell layer thickens and marginal basal cells migrate over the wound defect within hours after injury
New epithelial cells for wound closure are provided by fixed basal cells in a zone near the edge of the wound
Their daughter cells flatten and migration over the wound matrix as a sheet
Keratinocytes become columnar an