task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
Theory
In general, preparation methods for nanoparticles make use of capping agents, such as surfactants, polymers or biomaterial, in order to confine the growth. Occasionally, the selective or preferential adsorption of capping agents onto particular crystallograp- hic facets during the growth stage permits diverse shapes to be produced, for example triangles, hexagons, disks, rods and multi
and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles’
Size
Shape
Surface area
Permeability
ex) liposome, polymer, quantum dot, magnetic particle, carbon nanotube, nanoshell
1.Nano
어원 : 그리스어 ‘nanos’ – 난쟁이
SI 단위계에서 10-9
1 나노미터(nm): 10억분의 1m
Nanotechnology :
Research and technology development at the atomic, molecular, or macromolecular levels, in the length scale of approximately 1~100nm range
The medical application of nanotechnology
나노물질이 갖는 특유의 성질을 질병의 진단, 치료
nanoparticles that can carry the drug molecules to the target safely.
5.2.2 Nanocarriers - Nanoparticles
Before starting with the functionalization of nanoparticles, it is important to keep in mind a range of useful properties we wish to have in any drug delivery across the BBB(Blood brain barrier). In this context, owing to their small size, customizable surface, improved solubility, tar