Obesity is a medical condition in which excess body fat has accumulated to the extent
mainly defined by BMI
Diet (over nutrition)
Genetics
Medical and psychiatric illness
Social determinants
Infectious agents
Leptin is a protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
produced primarily in the adipocytes
History of sulfonylurea
IPTP for typhoid fever(장티푸스) in early 1940s
Many patients died. – acute & prolonged hypoglycemia
Carbutamide
effective oral hypoglycemic
Firtst sulfonyluea hypoglycemic