Complications
Thrombosis, fat embolism은 사망할 수 있으므로 주의 요함.
(General complications) fat embolism, ecchymosis, swelling, hematoma, infection, paresthesia, DVT
수술 후 24시간 이내 or 2-3일 후 dyspnea 발생시 fat embolism syndrome의심.
(Costmetic complications) 피부 착색, 피부자극증상, 피부면 울퉁불퉁함은 대개 6개월 이내 호전, 조
Development background
2. History of development
1960s
Discovery of colony-stimulating factors (CSF)
1980s
GM-CSF, M-CSF, G-CSF and multi-CSF
The human G-CSF was cloned
Usage for the treatment at first
1990s
first approval of Filgrastim by the US Food and Drug Administration
Launched Lenograstim
2000s
Launched PEG-filgrastim
repair physical damage. A growing trend in biomimicry is the creation of non-living structural materials that also have the capacity to heal themselves when cut, torn or cracked. Self-healing materials which can repair damage without external human intervention could give manufactured goods longer lifetimes and reduce the demand for raw materials, as well as improving the inherent safety of mater
DNA Repair
Mismatch repair
Base excision repair
Nucleotide excision repair
Direct repair
Mismatch repair
DNA polymerase 오류로 잘못 짝지어진 염기 복구
효소와 단백질
MutH, MutL, MutS 단백질
DNA helicaseⅡ, SSB
Exonuclease Ⅰ
DNA polymerase Ⅲ
DNA ligase
유전성 비용종성 대장암(hereditary nonpolyposis colon cancer, HNPCC)
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