of the COX and the product then reduced to a second endoperoxide PGH2 at the peroxidase site. Subsequent formation of prostaglandin end products from PGH2 depends on the presence of specific synthases that produce the functionally important prostanoids PGD2, PGE2, PGF2, PGI2 (prostacyclin) and TXA2 (thromboxane). These prostaglandins may undergo facilitated transport out of the cell by prostaglan
3. Dye-termination sequencing
Utilizes labelling of the chain terminator
Each of the four dideoxynucleotide chain
terminators is labelled with fluorescent dyes
Now being used for the vast majority ofsequencing projects
Challenge: differences in the incorporation of the dye-labelled chain terminators
into the DNA fragment
Blast
The Basic Local Alignment Search Tool
Development background
2. History of development
1960s
Discovery of colony-stimulating factors (CSF)
1980s
GM-CSF, M-CSF, G-CSF and multi-CSF
The human G-CSF was cloned
Usage for the treatment at first
1990s
first approval of Filgrastim by the US Food and Drug Administration
Launched Lenograstim
2000s
Launched PEG-filgrastim
Clinical Trials
Ⅰ. About Clinical Trial.
1. Definition of clinical trials
Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.
2.
of distractor, flanker task in this research, and whether the conflict resolution relies on a single central process or on a collection of independent control mechanisms that handle different types of conflict.
We intend to reveal some of the basic features of inhibition process for better understanding of cognitive control. Here are some characteristics of inhibition process proposed by various