thromboxane A2, ADP, serotonin (5-hydroxytryptamine), thrombin과 같은 다양한 인자들이 혈소판에서 분비됨으로써 이루어진다.(2) 따라서 항혈소판제제는 이러한 인자들과 연관되어 있는 대사 경로나 활성화 경로를 막음으로써 개발되어왔으며 심혈관질환의 발생을 예방하는데 임상적으로 좋은 결과들을 가져왔다.(3)
thromboxane A2( vasoconstriction)
further platelet activation, potential resistance to thrombolysis
2) → conformational change in the glycoprotein ⅡbⅢa receptor.
→high affirnity for the sequence arginine-glycine-aspartic acid on the fibrinogen gamma chain
→ platelet cross-linking and aggregation
B. coagulation cascade is
reduced to a second endoperoxide PGH2 at the peroxidase site. Subsequent formation of prostaglandin end products from PGH2 depends on the presence of specific synthases that produce the functionally important prostanoids PGD2, PGE2, PGF2, PGI2 (prostacyclin) and TXA2 (thromboxane). These prostaglandins may undergo facilitated transport out of the cell by prostaglandin transporters (PGT) and ot