Introduction
Nowadays, the method of chemotherapy + radiation is widely used because it is more effective for cancer cells than normal cells.
However, patient’s quality of life is directly related to the targeting ability of treatment, so that method has some side effects.
So finding less toxic agents and choosing a precise delivery system is a task currently important.
Regulation of nan
Tumor Escape
림프구의 항암활동 but 면역계는 간의 발암을 억제하지 못함
면역 편집(immunoediting) : 특정 암이 면역학적 감시로부터 회피하는 현상
FAS와 INFγ의 하향조절 at 간암 세포의 CD8+ T세포
대식세포 : PD-1을 발현한 CD8+ T 세포의 작용을 제한하는 억제성 분자 발현
IL-10(면역
tumor cell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express an enzyme, then
implanted the transduced NSCs along with a rat glioma cell line intracerebrally into nude mice. A
therapeutic effect was observed, but it required a 1:2 ratio of NSCs to glioma cells. Another group of
investigator
Tissue distribution of macrophages
대식세포는 자신의 해부학적 위치와 기능적 표현형에 따라 소집단으로 나누어진다. 전문조직에 상주하는 대식세포는 파골세포(뼈), 폐포 대식세포(폐), 조직구(간질성 결합조직), 쿠퍼세포(간)등이 있다. 창자에는 구분되는 표현형과 기능을 가진 다양한 대식세포와 수지상세
Pain의 기전
VISCERAL PAIN
Visceral pain is transmitted by C fibers that are found in muscle, periosteum, mesentery, peritoneum, and viscera. Most painful stimuli from abdominal viscera are conveyed by this type of fiber and tend to be dull, cramping, burning, poorly localized, and more gradual in onset and longer in duration than somatic pain. Because abdominal organs transmit sensory af