HIF가 저산소증에서 안정화 glucose lactate 전환
HIF-1은 산소에 민감한 HIF-1α subunit과 HIF-1β subunit이heterodimer를 형성하여 DNA 에 결합
HIF-1의 안정화는 angiogenesis를 유발
산소가 풍부한 상황에서 HIF-1α는 PDH(prolyl hydroxylases)에 의해TCA cycle에서 나온 a-ketoglutarate를 사용하여 hydroxylated
Tumor suppressor 단백
STEP1: ABOUT SKIN CANCER
Cause of cancer _ 2 cases
1.Cell growth doesn’t stop
2.Disorder of apoptosis
p53 : Tumor repressor gene
P53 : transcription factor
Functions
-p53 are that first arrest cell cycle so control cell growth, also active apoptosis suicide program
P53 mutation ->p53 sytem breaks down, it can’t act as Transcriptor factor-> generating tumor
1. Introduction of NVP-BEZ235
NVP-BEZ235 소개
Novartis
스위스 바젤에 본사를 두고있는 다국적 제약회사로 세계
각지에서 연구소를 운영중
1996년, 스위스에서 가장 큰 두 개의 제약·의료업체인
시바 가이기(Ciba-Geigy)와 산도즈(Sandoz)의 합병을
통해 설립
2010년 기준 총 매출액 세계 2위(506억 US $)
2010년
Enamel
√ Hard and white substance covering the teeth
√ The hardest and most highly mineralized
√ Protects the fragile underlying parts of the teeth
√ Covers the crown and supported by dentin
Component of enamel
√ 96% of enamel : mineral, water, organic material
√ contain two unique classes of proteins amelogenins and enamelins
√ The basic unit of enamel is called
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp