1908 - The term "stemcell" was proposed for scientific use by the Russian histologist Alexander Maksimov (1874–1928) at congress of hematologic society in Berlin. It postulated existence of haematopoietic stemcells.
1998 - James Thomson and coworkers derive the first human embryonic stemcell line at the University of Wisconsin–Madison.
2004–2005 - Korean researcher Hwan
Discovery of the iPS cell
Expect to solve the problems of ES cells
How to think?
Active factor(protein) in ES cells skin cells
Aug, 2006, Pro. Yamanaka ’s laboratory in Kyoto produced ‘pluripotent cells’
Nov, 2007, the first Human iPS cells
iPS cells are a type of pluripotent stemcell
artificially derived from a differentiated cell,
by inducing a “forced”
★빈혈의 치료
빈혈의 치료는 원인에 따라 다르다. 단순한 철결핍성 빈혈이라면 철분공급으로 쉽게 교정된다. 빈혈의 치료는 원인뿐 아니라 빈혈의 정도에 따라서도 다르다.
최근 수혈을 원하는 환자는 줄고 있으나, 아직도 수혈을 선호하는 사람들이 있는데, 여러 부작용을 고려할 때, 꼭 필요한
stemcells by using needle
4. Blood transfusion(수혈)
of him or her prepared blood
5. Take hemostasis(지혈) & painkiller
6. Make a recovery for 1 week
From Peripheral Blood
More easy way!
Just like apheresis(성분헌혈)
1. Inject G-CSF (stimulate growth of HSCs) during 5days
2. Apheresis like blood donation
It takes only 4 to 6 hours
And no need any anesthesia(
Stemcell calssification
1. Based upon location
Embryonic stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re