Mid-1800s - Beginning research of Embryo
1908 – ‘StemCell’ from Alexander Maksimov
1963 – Self reproducing cell
1978 – Found Blood stemcell
1981 - Embryonic stemcell
1998 - Human's embryonic stemcell
2001 – First human embryo cloning
(중략)
2.1 Adult StemCell - How?From Bone Marrow
HSCs and MSCs are rich in b
Stemcell calssification
1. Based upon location
Embryonic stemcells
Somatic/ adult stemcells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
stemcells" (iPS), claiming it to be the 'ultimate stemcell solution'.
11 October 2010 - First trial of embryonic stemcells in humans.
ESC
장점
-거의 모든 세포로 분화 가능
-무한정 증식이 가능
-핵 이식을 통해서 환자 맞춤형 치료
단점
-인간 복제의 가능성
-윤리적 문제(인간복제)
-난자 획득의 어려움
ASC
장점
A. Limitations
So far we have seen a new approach of using stemcells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stemcells esp
mesenchymal cell(미분화중간엽세포)
① mesenchymal cell이 아직 미분화 상태로 남아 있는 것.
(대개 mesenchymal cell은 fibroblast같은 여러 결합조직 내 여러 세포로 종류가 결정되어 분화하나, 종류가 결정되지 않고 미분화된 상태로 남아 있는 세포이다. 존재 여부가 아직 불확실하다.)
② 대개 blood vessel(특히 capill