Lipopolysaccharides (LPS), also known as lipoglycans,
are large molecules consisting of a lipid and a polysaccharide
joined by a covalent bond; they are found in the outer
membrane of Gram-negative bacteria, act as endotoxins and
elicit strong immune responses in animals.
LPS is the major component of the outer membrane of
Gram-negative bacteria, contributing greatly to the structu
of peptide that cause stimulation of target organ should be the same
⑤ The assay must not measure biologically inactive degradation product
⑥ It should be possible to prevent the physiologic response by removing the peptide from the blood or by specific antagonism at its receptor
1.Gastrin
Action
major hormonal stimulant of gastric acid secretion
trophic action to gastric mucosa
hormone excess and is not synonymous with hyperthyroidism
But, the major etiologies of thyrotoxicosis are hyperthyroidism caused by Grave’s disease, toxic MNG, and toxic adenomas
2. Pathogenesis (cont.)
Polymorphisms in HLA-DR, CTLA-4, and PTPN22 (a T cell regulatory gene)
The concordance for grave’s disease
- in monozygotic twins : 20-30%
- in dizygotic twins : <5%
by up-regulating of carnitine palmitoyl transferase(CPT)-1 and acyl CoA oxidase(ACO) which are target enzyme of FA oxidation
It can be considered on that fact that in the WAT expression of PPARα is occurred but in the PPARα -/- condition expression of PPARα mRNA is not occurred.
PPARα+/+
PPARα-/-
Apetite 3
Decreased(32%)
Decreased(37%)
Weigh
Socioeconomic Factors
No significant differences were found between cases and controls on most of the variables.
employment groups (p = 0.029)
meat consumption (p = 0.012)
chicken consumption (p = 0.034)
Malnutrition
세포매개면역을 저하시킨다.
higher point prevalence of infection in undernourished patients or community dwellers
worse and more frequent complications of infect