Abstract
Abacavir (ABC) is a nucleoside analog reverse trascriptase inhibitor (NRTI) used to treat HIV and AIDS. The pharmacogenetics of abacavir are relate to the human leukocyte antigen B (HLA-B) gene and its variant allele *57:01. This particular allele has been strongly associated with abacavir hypersensitivity. Limited research has been conducted in this area, though some potential exists
fusion)시켰을 때 정상세포의 종양억제유전자가 활동하여 암세포의 악성표현형이 억제되었다는 보고에서 건강생활양식이 암재발 예방에 중요하다는 것을 유추할 수 있다.
또한 위암은 질병자체 뿐 아니라 치료의 부작용과 재발가능성으로 삶의 질에 부정적인 영향을 주므로, 단순히 생존율과 치료율로
(2) Active targeting
Nanoparticle passive targeting can be enhanced by ‘active targeting’, where specific ligands (peptides, antibodies, aptamers, or small molecules) are attached to the nanoparticle surface to bind receptors/antigens overexpressed on cancer cells. Targeting increases accumulation in tumors and lessens exposure to healthy tissue, which can improve a toxic drug’'s therape
with axial skeleton predominance
Affects 0.1-0.2% of the population
90-95% of patients are HLA-B27 positive
7% of general population is positive, only 1% of positives will develop ankylosing spondylitis
Male:female 4-10:1
Ankylosis of sacroiliac joints
Syndesmophytes in the lumbar spine
Fusion of the interspinous ligament
Arthropathy of both hips
Enthesopathy of ischial tuberosity
Histoplasmosis
Acquired by inhalation of dust particles from contaminated soil
Markedly resemble Tbc
Macrophages are the major target of infection
Patients with acquired immunodeficiency syndrome are susceptible to disseminated infection with Histoplasma (opportunistic pathogen)
Diagnosis
Culture
Identification of the fungus in tissue lesions.
Serologic tests for antibodies and antigen.