cells of the epidermis)
표피를 구성하는 세포는 keratinocyte, melanocyte, merkel cell 및 Langerhan's cell이다.
(1) Keratinocytes
표피세포 중 keratinocyte가 가장 많이 존재하며 이 세포의 주된 기능은 표피의 protective 기능을 나타내는 fibrous 단백인 keratin을 생성하며 이들 세포는 desmosome이라는 구조로서 2 개의 세포가 단
D와 T은 남성호르몬 수용체와 결합하여 핵내로 이동하여 전사인자로 작용, D는 T보다 결합력이 강하여 강력한 전사 활성화를 유도한다.
체모의 경우 모모세포의 증식을 촉진하는 인자(IGF1)가 만들어지는 반면, 전두부나 두정부에서는 모모세포의 증식을 억제하는 물질이 만들어 진다.결국 남성형탈모는
immunogenic cells such as
dendritic cells and capillary endothelial cells,
it is not rejected by the body.
- Rehabilitation time is significantly reduced.
- Alternative to animal testing
The problem of interaction between epidermis and dermis
Spontaneous blistering
2 step procedure
The application of various tests or treating diseases
Regeneration of sweet gland and follicle
Stem cell calssification
1. Based upon location
Embryonic stem cells
Somatic/ adult stem cells
2. Based upon function
Totipotent
Pluripotent
Multipotent
Unipotent
Reject Response
Traditional Immuno-repressents
Constant administration
Little engraftment after 3~4 weeks
Host immune system impaired
Vulnerable to Infection
↓Need brief immuno-re
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells esp