P2
Location
Human chromosome 7
7q31, at the SPCH1 locus
FOXP2 orthologs are in all mammals
Require for proper brain and lung development
Mutation of FOXP2
Cause a severe speech and language disorder (Human)
Study of mice and songbirds
Differences of FOXP2 between Human and Animals
Chimp : 2 Amino Acids
Mouse : 3 Amino Acids
Zebra finch : 7 Amino Acids
Neanderthal : Same Version
human neural progenitor cell을 in vitro에서 배양하며 일련의 signals에 노출시켰는데, 이 때의 signal은 in vivo에서 pancreatic islet development에 관여된 것들이다. 이러한 세포 배양의 결과, neural cell에서 pancreatic islet의 in vivo 조절인자의 발현이 확인되었다. 또한 이 세포를 immunocompromised mice에 transplant한 결과에서도 높은
The Master of our bodies: Microflora !
*서론
요즘 고지방, 고단백 위주로 식단이 바뀌면서 대장암이 급속히 증가하고 있다.
또 스트레스, 과로, 불규칙한 생활 습관 등으로 인해 설사, 변비, 더부룩함, 장염 증상으로 고생하는 사람들도 늘고 있다.
우리의 장에는 수많은 세균들이 우리와 함께 살아가고
Microflora ?
Consists of microorganisms that live in the digestive tracts of animals and is the largest reservoir of human flora.
“forgotten” organ
Bacteria up to 60% of the dry mass of feces
If bacterium has 1㎛ diameter, the length of 100 trillion bacteria is about 100 thousand kilometer.
It means we can turn around the earth twice and half with these bacteria.
Functions of gu
diseases.
Essential to be able to direct this development to form only the wanted type of cells
Gene targeting in ES cell
1. ES cell culture
2. Construction of targeting vector
3. ES cell transfection
4. Proliferation of targeted ES cell
From gene targeted ES cells to
gene targeted mice
5. Injection of ES cells into blastocysts
6. Birth and breeding of mosaic mice