light chains: 40 V x 5 J = 200
light chains: 30 V x 4 J = 120
H chains: 40 VH x 27 DH x 6JH = 6,480
320 L chains x 6,480 H chains = 2.1 x 106
Junctional diversity (addition or deletion of nucleotides at recombination sites, especially of H chain), estimated to add 3x107 fold to overall diversity.
Recombination signals
Rag-1/Rag-2/Artemis
Immunoglobulin E
in health and disease
Basic characteristics of IgE
IgE is the antibody isotype that contains the ε heavy chain and it is a monomer with five domains in the immunoglobulin structure
in plasma
- concentration of less than 1 μg/mL
in serum
- a half-life of about 2 days
Basic characteristics of IgE
IgE binds to its receptor FcεR,
High-affinity receptors (FcεRI)
-wide var
면역글로불린(Immunoglobulin)-항체(Antibody)
1. 항체(Antibody)
• 항원과 특이적 결합을 하여 항원-항체 반응을 일으키는 물질이다
• 신체에 침입한 미생물에 대항하여 세포 외부 자극을 유도하는 당단백질이다.
• 동종항체, 면역항체 ― 동종항체(정상항체)는 혈액의 혈소판이 적혈구와 반응하 여
* Omalizumab (Xolair) is the 149 kDa, glycosylated antibody which is produced by an engineered CHO cell line. This recombinant humanized monoclonal antibody blocks the high-affinity Fc receptor of immunoglobulin E (IgE). It is used to treat patients with moderate-persistent to severe-persistent asthma.The product was approved in the EU in 2005, although it has been available in the US since 2