Integrin αvβ3
Integrin αvβ3 is the method for active targeting. Most of cancer cell have these receptor. Selection of molecules which target this receptor should be made.
For our strategy to use double targeting, we use special peptide pHLIP(pH Low Insertion Peptide). Cancer cells accumulate pyruvate due to insufficient O2 and consequent decrease of oxidative phosphorylation. So H+ pump
History
The first historical account of MD was reported by Conte and Gioja in 1836
Guillaume Duchenne - first case of MD.
Professor Becker - a less severe form of muscular dystrophy in 1955
What is Muscular Dystrophy?(MD)
Muscular Dystrophy (MD) is a group of muscle diseases that weaken the musculoskeletal system
The main cause : the muscle tissue's cytoskeletal impairment t
3. Structure
Figure 1. Structure of icosahedral capsid
The virus particle (25-30 nm) has and icosahedral capsid made of protein(figure 1), without envelope, containing a single-strand of ribonucleic acid(ssRNA) containing a positive encoding of its genome.[3] This positive-sense ssRNA is genome of approximately 8,400 nucleotides.[4] The virus capsid is made up from 60 copies each of four virus-
RNA Virus 61664; Picornaviridae
61664; Aphthovirus 61664; FMDV
Specified as 7 serotype
(O, A, C, SAT1, SAT2, Sat3, Asia1)
and 80 subtype
Serotype O is most common and current damage was caused by it
21-25 nm nonenveloped capsid virus
Icosahedral capsid structure containing ssRNA
Virus Capsid: made up from 4 encoded proteins (VP1~VP4)
VP1~VP3: capsid shell, VP4: inter
나) 폐에서 surfactant의 역할을 설명하시오.
Type II 폐포상피세포에서 분비되는 surfactant는 폐포 내의 표면장력을 감소시켜 작은 압력으로도 폐포가 열리도록 하며 폐포의 크기에 따라 표면장력을 변화시킴으로써 폐포의 확장을 유지시킨다.
Surfactant 는 표면장력을 감소시켜 줌으로서 폐가 쉽게 확장할