Journal review
Effects of vitamin E on stroke subtypes: meta-analysis of
randomised controlled trials
BMJ 2010;341:c5702
Introduction
Vitamin E - lipid soluble antioxidant
inhibit lipid peroxidation by scavenging reactive oxygen species
Cardiovascular disease - atherogenesis
Key role : lipid peroxidation
randomised, placebo controlled trials of vitamin E on incident stroke and stroke subtypes
Me
이 연구는 2008년까지 IVF 시술 시에 침치료를 받은 여성들에게서 침치료가 얼마나 효과적이었는지 연구한 문헌들을 메타분석 기존의 문헌 연구에서는 관심있는 변수들간의 효과가 통계적으로 있는 연구도 있고 없는 연구도 있다는 등의 결과를 기술하는데에서만 머물기 때문에 결론적으로 효과가 있다
meta-analysis of RCT of salt reduction (2002)
<6g/day
SBP/DBP 7/4mmHg ↓ (with HTN), 4/2mmHg ↓ (without HTN)
24% for stroke, 18% for coronary heart disease ↓
Introduction
Prospective cohort studies performed in the past three decades that measured the levels of dietary salt intake at baseline and recorded the incidence of vascular events have provided important indirect evidence.
Systemat
meta-analysis of RCTs. Buscemi N, Vandermeer B, Friesen C, Bialy L, Tubman M, Ospina M, Klassen TP, Witmans M, J Gen Intern Med. 2007;22(9):1335.
Meta-analysis of benzodiazepine use in the treatment of insomnia. Holbrook AM, Crowther R, Lotter A, Cheng C, King D, CMAJ. 2000;162(2):225.
에서는 benzodiazepines계 약물들이 수면의 지연을 감소시키고 잠이 깨는 횟수를 줄이며,
Dietary magnesium intake and risk of stroke:
a meta-analysis of prospective studies1-4
Susanna C Larsson, Nicola Orsini, and Alicja Wolk
Am J Clin Nutr 2012;95:362-6.
INTRODUCTION
Magnesium
inversely associated with risk factors for stroke such as hypertension, metabolic syndrome, type 2 diabetes
reduces diastolic blood pressure, fasting C-peptide and insulin concentrations
animal studies
favo