We have shown that in colonic smooth muscle, PKC-α and RhoA translocate and associate with each other in the particulate fraction in response to stimulation with acetylcholine.
We have also shown that RhoA interacts directly with PKC-α in vitro.
1) In human endothelial cells, activation of ROCK by RhoA requires PKC activation .
(1998,Hippenstiel S et al)
2) We have recentl