recombinant human G-CSF 이 E. coli expression 에 의해 처음 filgrastim 합성되어졌고, filgrastim의 구조는 자연 glycoprotein과 살짝 다를 뿐이다. Filgrastim (Neupogen) and PEG-filgrastim (Neulasta) 은 두개의 상업적으로 이용가능한 rhG-CSF (recombinant human G-CSF)이다. US Food and Drug Administration에 의해 1991년, chemotherapyinduced Neutropenia 환자
1,3-Galactose
Glycoprotein that exists on surface of organs and causes hyperacute rejection
α1,3-Galactosyltransferase
Enzyme that transfer α1,3-Galactose formed inside cell to surface of cells
Solution of Problems that HAR Has.
1) Inactivation of complements
The way to insert genes that express complements repression factor
2) α1,3-G
11과에 나오는 glycoprotein에 대해서이다. 피(blood)에서 중요하게 여기는 것 중 하나가 혈액형이다. 우리가 수혈을 해줄 때 제일 먼저 따지는 것이 혈액형이며, 아플 때 수술할 때 따지는 것도 바로 혈액형이다. 그 중에서 가장 잘 알려져 있는 혈액형이 ABO 혈액형이다. ABO 혈액형을 수혈할 때 수혈관계를 따
3. Structure
Figure 1. Structure of icosahedral capsid
The virus particle (25-30 nm) has and icosahedral capsid made of protein(figure 1), without envelope, containing a single-strand of ribonucleic acid(ssRNA) containing a positive encoding of its genome.[3] This positive-sense ssRNA is genome of approximately 8,400 nucleotides.[4] The virus capsid is made up from 60 copies each of four virus-
11; Method
The efficacy of RELENZA 10 mg inhaled twice daily for 5 days in the
treatment of influenza has been evaluated in placebo-controlled
studies conducted in North America, the Southern Hemisphere,
and Europe during their respective influenza seasons.
The principal Phase III studies enrolled 1,588 patients ages 12 years
and older (median age 34