Channel protein
; hydrophilic pore
Ion channel - highly selective pore
open and close
passive transport-diffuse
Nerve cell - Ion channel 이용
Ion channels ion-selective and fluctuate between open and closed states
Ion channel 의 Property
-ion selectivity
-open and close(gate)
Specific stimulus에 의해 open
Contents
Ion channels ion-selective and fluctuate between open and closed states
The membrane potential in animal cells depends mainly on K⁺ leak channels and the K⁺ gradient across the plasma membrane
The resting potential decays only slowly when the Na⁺- K⁺ pump is stopped
The three-dimensional structure of a bacterial K⁺ channel shows how an ion channel can wo
is indicated
It often affects the ascending aorta and aortic arch, causing obstruction of the aorta and its major arteries
Pulseless disease
: frequent occlusion of the large arteries originating from the aorta
The pathology
: panarteritis, characterized by mononuclear cells and occasionally giant cells, with intimal hyperplasia, medial and adventitial thickening
Program (1) : Channels
Experiments (1-1) : Potassium Channels
A) The proability that the channel is open increases in a sigmoid manner with time. Explain why?
Potassium(K+) channel의 경우 Sodium channel(Na+)과 달리 inactivation gate가 없고 activation gate만 4개를 가지고 있으며, 이를 n gate라고 한다. 막전압의 변화는 세포막에 존재하는 전하를
cells of the epidermis)
표피를 구성하는 세포는 keratinocyte, melanocyte, merkel cell 및 Langerhan's cell이다.
(1) Keratinocytes
표피세포 중 keratinocyte가 가장 많이 존재하며 이 세포의 주된 기능은 표피의 protective 기능을 나타내는 fibrous 단백인 keratin을 생성하며 이들 세포는 desmosome이라는 구조로서 2 개의 세포가 단