three more patients will be treated.
Continual Reassessment Method(CRM)
All patients are
treated maximum tolerated dose.
(MTD)
The original CRM allowed for multiple dose escalations and de-escalations.
Accelerated
Titration
Design(ATD)
Standard design is used after the accelerated phase as a stopping rule.
Estimate the MTD with all toxicity data collected during the trial.
Clinical Trials
Ⅰ. About Clinical Trial.
1. Definition of clinical trials
Although there are many definitions of clinical trials, they are generally considered to be biomedical or health-related research studies in human beings that follow a pre-defined protocol. Observational studies are those in which individuals are observed and their outcomes are measured by the investigators.
2.
Clinical test
Clinical trial is limited to human, therefore it is the precondition that ensuring ethicality with scientific validity of study.
Necessity of Clinical test
- Developing a new drug for Korean inherited trait
- Offering the earliest opportunity to patients
- Strengthening the capability of researchers
- Clinical trial has high added value
It is a plan th
2. 이론
(1) Fresnel equation
전자기파인 빛은 두 개의 서로 다른 물질을 통과할 때, Maxwell의 방정식에 따른 boundary condition을 만족한다. 이에 따라 식을 전개하면 물질을 들어가기 전과 후의 전기장의 크기 차이의 비를 알 수 있고, 이것이 곧 반사율이 된다.
그림. TE wave의 반사율
그림. TM wave의 반
턴어라운드의 비결
TRUST
신뢰는 생명이다.
철저한 정리계획안의 실천
“임직원 월급을 하루 늦게 주는 한이 있더라도 법원에 제출한 정리 계획안은 20년 동안 하루도 어기지 않고 지켰으며, 오히려 초과달성하도록 노력했습니다.”
이윤재 회장 소감문 中
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