of cigarette smoke-induced proinflammatory mediator release via sirtuin-NF-κB RelA/p65 interaction. Cigarette smoke decreased sirtuin levels and caused posttranslational modification by reactive aldehydes/reactive oxygen species/RNS, thereby disrupting SIRT1-RelA/p65 complex via phosphorylation (P) and acetylation (Ac) of RelA/p65. This leads to increased release of pro-inflammatory mediators.
of inhibiting cyclooxygenases involved in the formation of prostanoids. Prostanoids areformed by most cells and act as autocrine and paracrine lipid mediators. They are not stored but are synthesized de novo from membrane-released arachidonic acid mobilized by phospholipases (PLA2) when cells are activated by mechanical trauma, cytokines and growth factors, etc. Conversionof arachidonic acid to p
angigogenesis를 감소시킨다. 또한 MMP-1과 MMP-3도 감소시킨다. 이러한 것들이 bone damage를 감소시키는 것처럼 보인다.
3. Systemic lupus erythematosus
A. Systemic lupus erythematosus란?
a. Definition
Systemic lupus erythematosus (SLE, 전신성 홍반성 루푸스)는 clinically heterogeneous disease인 auto immune disease로써, nuclear antigen에
of compounds recently identified key to the anticancer properties of cruciferous vegetables, most active isothiocyanate is sulfor-aphane.
Dosage: 500 to 2000mgs daily in divided oral dose.
Sprouts contain 20 to 50 times more sulforaphane in much greater quantity than mature broccoli.
Boiling reduce the levels of anti-cancer compounds in broccoli
Safety - No toxic data available, generally
Immune surveillance(면역 감시)
“Sensing function “
- T cell : 암세포 감시, 제거
- oncogene의 활성화 or oncogenic event
세포스트레스 상태를 유도
세포노화 or 세포자살 유도
- CD4+ T Cell
세포노화 감지
대식세포가 노화세포를 제거하도록 면역반응 유도
- Th1 cytokine인 IFNγ or TNFα
암세