Ⅰ. 유전자조작의 의의
분자생물학의 눈부신 발전에 따른 생명공학기술의 확립을 통하여 유전자변형동물 즉, 형질전환동물(transgenic animal)과 유전자결손동물(knock out animal)의 개발은 질환모델동물의 개발과 연구에 더욱 박차를 가하게 되었다. 유전자 조작법을 이용하여 특정유전자의 기능을 확인하는
the nude?
SEBASTIAN
I cracked the reversion.
Upon hearing this, Linda receives a jolt of adrenaline.
LINDA
You cracked it?
SEBASTIAN
Look at this.
Sebastian hits a couple of keys. A moment later the
molecular structure appears on Linda s computer.
SEBASTIAN
Watch this.
LINDA
You sure?
SEBASTIAN
91% sure.
LINDA
(astonished)
Eleven months with no progress and you
suddenly come up with it out of
mous.
[Continues, Indistinct]
Hes an Exonion.
His sons were charming boys...
but... mediocre students.
Why do cautionary tales for children
come so naturally to you?
They were both in my class.
Well, I think I can imagine
their fears and express them.
Um, in my stories,
Anyway,
uh, you can see whats coming,
but you dont see everything thats coming.
just pick up what you can.
Note his work habits.
Immune surveillance(면역 감시)
“Sensing function “
- T cell : 암세포 감시, 제거
- oncogene의 활성화 or oncogenic event
세포스트레스 상태를 유도
세포노화 or 세포자살 유도
- CD4+ T Cell
세포노화 감지
대식세포가 노화세포를 제거하도록 면역반응 유도
- Th1 cytokine인 IFNγ or TNFα
암세
Its magnified and deeply revealed. Flecks of green and yellow in a field of milky blue. Icy filaments surround the undulating center.
The eye is brown in a tiny screen. On the metallic surface below, the words VOIGHT-KAMPFF are finely etched. Theres a touch-light panel across the top and on the side of the screen, a dial that registers fluctuations of the iris.
The instrument is no bigger than a